Pharmacogenetics of Drug Receptors
نویسنده
چکیده
Drug treatment is in many cases ineffective. Besides patients who do not respond to the treatment can develop so called adverse drug reactions (ADRs) as a consequence of the treatment (cause over 100 000 deaths per year in USA). Pharmacogenetics is the discipline, which takes the patient’s genetic information of drug transporters, drug metabolising enzymes and drug receptors into account leading to optimal choice and dose of the drugs in question. It represents a kind of patient-oriented medicine or personalized medicine. It is believed that a lot of costs for the society can be saved by so called individualized drug therapy mainly based on pharmacogenetic data.
منابع مشابه
I-33: Pharmacogenetics of Reproductive Medicine
Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. Inter-individual genetic differences can have significant roles in determining an individual’s susceptibility to ADRs. The rapid development of techniques in the area of genome analysis has put the scientific community in a power position and facilitated identification of new pharmacogenomic biomarkers that ...
متن کامل7. Pharmacogenetics of Drug Receptors
Drug treatment is in many cases ineffective. Besides patients who do not respond to the treatment can develop so called adverse drug reactions (ADRs) as a consequence of the treatment (cause over 100 000 deaths per year in USA). Pharmacogenetics is the discipline, which takes the patient’s genetic information of drug transporters, drug metabolising enzymes and drug receptors into account leadin...
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Large differences among normal human subjects in the efficacy and safety of many therapeutic agents are caused by genetically controlled polymorphisms of drug-metabolizing enzymes, drug transporters, and drug receptors. Development of pharmacogenomics as a new field has accelerated progress in pharmacogenetics by elucidating at the level of the human genome the inherited basis for those large i...
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Polymorphisms in the genes that code for drug-metabolising enzymes, drug transporters, drug receptors, and ion channels can affect an individual's risk of having an adverse drug reaction, or can alter the efficacy of drug treatment in that individual. Mutant alleles at a single gene locus are the best studied individual risk factors for adverse drug reactions, and include many genes coding for ...
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Pharmacogenetics is moving rapidly to assemble a large set of polymorphisms that define the influence of genetic diversity on human drug response. Scientific and technological advances of the last 10 years have led to new approaches to the discovery of genetic drug susceptibility loci, the development of high-tech analytical strategies for drug susceptibility profiling, and a flood of new gene ...
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